Hex Fiend 2
Peter Ammon has released Hex Fiend 2 and an open-source framework for embedding it:
This app is about exploring the implementation of standard desktop UI features in the realm of files too large to fully read into main memory. Is it possible to do copy and paste, find and replace, undo and redo, on a document that may top a hundred gigabytes, and make it feel natural? Where do we run into trouble?