Whoosh 2.0
Whoosh (via Gus Mueller):
Whoosh helps you send out lots of emails using the Amazon Simple Email Service. Whoosh will import mailing list in CSV or Tab-Delimited format from a file, or direct from a remote URL.
I’m currently using DreamHost for my announcement mailing lists. I use Amazon SES for all other auto-generated e-mails—e.g. order confirmations and serial number lookups—but I’ve long thought of using SES for announcements as well. It works really well and is orders of magnitude cheaper than MailChimp and similar services.
Update (2014-09-20): Scott Morrison recommends Sendy, a self-hosted PHP/MySQL tool that uses Amazon SES and also helps you manage the subscription list.