Firefox 3 vs. Safari 3
The main reason I switched from Safari to Firefox in the first place was memory consumption on my PowerBook G4—after just a few hours of my use, Safari 3 inevitably consumes at least 300 MB, often more, of private memory. In the same usage, Firefox 3 never seemed to use more than 90 MB, even after a few days.
But for this I really, really like Safari.