The users who have likely had the most “success” (using the term loosely) with replacing Office are likely the individual users I mentioned early on who are simply using Office documents as containers, not using any Office specific features to much depth, and can likely survive just using the document export features in Google Docs, iWork, or any other Web/mobile productivity suite not from Microsoft. Admittedly, Microsoft surely sees this scenario, and as such has made the Office Web Apps for consumers freely available and interconnected with SkyDrive.
Even the Mac version of Office is not always a viable substitute. And I’ve seen iWork documents destroyed when moving from Mac to iPad, to say nothing of using it to edit actual Word or Excel documents.
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